Casil.io Next-generation CRISPRCas9 platform
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The Jackson Laboratory for Genomic Medicine. The Cheng lab develops technologies based on artificial DNA and RNA binding proteins and applies them to sense or induce sequence or epigenetic changes at target genomic loci or target transcripts. Developing novel approaches for epigenetic and transcript editing. Developing sensors for DNA and RNA. Developing imaging techniques for 3D structure of the genome.
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Casil.io Next-generation CRISPRCas9 platformDESCRIPTION
Without permanently changing genetic sequences. The problems and previous solutions. Our solution to both the multiplexing and multimerization problems Casilio. We have constructed an RNA-aptamer based approach called Casilio to improve both multiplexing and multimerization capabilities to CRISPRzyme toolkits 19. Casilio is a hybrid system combining CRISPRd Cas. 9 and Pum ilio. The components of Casilio using Sp-dCas9. Cas9 with D10A and H840A mutations. List of vectors expressing sgRNA-PBS. One-s.CONTENT
This website casil.io states the following, "The problems and previous solutions." We analyzed that the website also said " Our solution to both the multiplexing and multimerization problems Casilio." It also stated " We have constructed an RNA-aptamer based approach called Casilio to improve both multiplexing and multimerization capabilities to CRISPRzyme toolkits 19. Casilio is a hybrid system combining CRISPRd Cas. The components of Casilio using Sp-dCas9. Cas9 with D10A and H840A mutations. List of vectors expressing sgRNA-PBS."SEEK OTHER DOMAINS
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